RSNA Press Release

• Visceral, or deep belly, obesity is a risk factor for bone loss and decreased bone strength in men.
• Most prior studies on osteoporosis have focused on women.
• More than 37 million American men over age 20 are obese.

CHICAGO—Visceral, or deep belly, obesity is a risk factor for bone loss and decreased bone strength in men, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

"It is important for men to be aware that excess belly fat is not only a risk factor for heart disease and diabetes, it is also a risk factor for bone loss," said Miriam Bredella, M.D., radiologist at Massachusetts General Hospital and associate professor of radiology at Harvard Medical School in Boston.

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Miriam Bredella, M.D.

According to the National Center for Health Statistics, more than 37 million American men over age 20 are obese. Obesity is associated with many health problems, including cardiovascular diseases, diabetes, high cholesterol, asthma, sleep apnea and joint diseases. Yet despite all the health issues, it was commonly accepted that men with increased body weight were at lower risk for bone loss.

"Most studies on osteoporosis have focused on women. Men were thought to be relatively protected against bone loss, especially obese men," Dr. Bredella said.

But not all body fat is the same. Subcutaneous fat lies just below the skin, and visceral or intra-abdominal fat is located deep under the muscle tissue in the abdominal cavity. Genetics, diet and exercise are all contributors to the level of visceral fat that is stored in the body. Excess visceral fat is considered particularly dangerous, because in previous studies it has been associated with increased risk for heart disease.

After the Osteoporotic Fractures in Men Study—a multi-center observational study designed to determine risk factors for osteoporosis—indicated that male obesity was associated with fracture risk, the researchers wanted to quantify belly fat and study its impact on bone strength.

Dr. Bredella and her team evaluated 35 obese men with a mean age of 34 and a mean body mass index (BMI) of 36.5. The men underwent CT of the abdomen and thigh to assess fat and muscle mass, as well as very high resolution CT of the forearm and a technique called finite element analysis (FEA), in order to assess bone strength and predict fracture risk.

"FEA is a technique that is frequently used in mechanical engineering to determine the strength of materials for the design of bridges or airplanes, among other things," Dr. Bredella said. "FEA can determine where a structure will bend or break and the amount of force necessary to make the material break. We can now use FEA to determine the strength or force necessary to make a bone break."

In the study, the FEA analysis showed that men with higher visceral and total abdominal fat had lower failure load and stiffness, two measures of bone strength, compared to those with less visceral and abdominal fat. There was no association found between age or total BMI and bone mechanical properties.

"We were not surprised by our results that abdominal and visceral fat are detrimental to bone strength in obese men," Dr. Bredella said. "We were, however, surprised that obese men with a lot of visceral fat had significantly decreased bone strength compared to obese men with low visceral fat but similar BMI."

The results also showed that muscle mass was positively associated with bone strength.

Coauthors are Eleanor Lin, M.D., Mary L. Bouxsein, Ph.D., Martin Torriani, M.D., Bijoy J. Thomas, M.D., Anu V. Gerweck, N.P., and Karen Miller, M.D.

Note: Copies of RSNA 2012 news releases and electronic images will be available online at RSNA.org/press12 beginning Monday, Nov. 26.

RSNA is an association of more than 50,000 radiologists, radiation oncologists, medical physicists and related scientists, promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

Editor's note: The data in these releases may differ from those in the published abstract and those actually presented at the meeting, as researchers continue to update their data right up until the meeting. To ensure you are using the most up-to-date information, please call the RSNA Newsroom at 1-312-949-3233.

For patient-friendly information on abdominal CT, visit RadiologyInfo.org.

Press conference video

Video clips

• .mp4 format
1. Video clip (842 Kbyte)
   Dr. Bredella discusses the methodology of the study.
2. Video clip (334 Kbyte)
   Dr. Bredella discusses the most important finding from the study.
3. Video clip (613 Kbyte)
   Dr. Bredella discusses what compelled her to do this research.
4. Video clip (645 Kbyte)
   Dr. Bredella discusses why the research focused on studying obese men.
5. Video clip (388 Kbyte)
   Dr. Bredella discusses what kind of fat is most damaging to bone strength.
6. Video clip (353 Kbyte)
   Dr. Bredella discusses how finite element analysis (FEA) is used.
7. Video clip (375 Kbyte)
   Dr. Bredella discusses what is surprising about the findings of the study.
8. Video clip (708 Kbyte)
   Dr. Bredella discusses how to prevent bone degeneration.
9. Video clip (1,248 Kbyte)
   Dr. Bredella discusses the difference between visceral and superficial belly fats.
10. Video clip (404 Kbyte)
    Video clip showing Dr. Bredella consulting with another radiologist in a reading room.
11. Video clip (212 Kbyte)
    Video clip showing a radiologic technologist putting a patient's arm in a computed tomography (CT) forearm scanner.
12. Video clip (282 Kbyte)
    Video clip showing a radiologic technologist putting a patient's arm in a brace before a computed tomography (CT) forearm scanner.
13. Video clip (338 Kbyte)
    Video clip showing Dr. Bredella consulting with a radiologic technologist.
14. Video clip (188 Kbyte)
    Video clip showing a radiologic technologist reviewing images.
15. Video clip (169 Kbyte)
    Video clip showing Dr. Bredella consulting with a patient.
16. Video clip (552 Kbyte)
    Video clip showing a radiologic technologist removing a patient's arm from a computed tomography (CT) forearm scanner.

Images (.JPG format)

Figure 1. Image acquired using a ScanCo Medical Xtreme CT scanner. High-res (TIF) version (Right-click and Save As)	Figure 2. Image acquired using a ScanCo Medical Xtreme CT scanner. High-res (TIF) version (Right-click and Save As)	Figure 3. Image acquired using a ScanCo Medical Xtreme CT scanner. High-res (TIF) version (Right-click and Save As)	Figure 4. Image acquired using a ScanCo Medical Xtreme CT scanner. High-res (TIF) version (Right-click and Save As)
Figure 5. Image acquired using a ScanCo Medical Xtreme CT scanner. High-res (TIF) version (Right-click and Save As)	Figure 6. Image acquired using a ScanCo Medical Xtreme CT scanner. High-res (TIF) version (Right-click and Save As)	Figure 7. Image acquired using a ScanCo Medical Xtreme CT scanner. High-res (TIF) version (Right-click and Save As)	Figure 8. Image acquired using a ScanCo Medical Xtreme CT scanner. High-res (TIF) version (Right-click and Save As)
Figure 9. Image acquired using a ScanCo Medical Xtreme CT scanner. High-res (TIF) version (Right-click and Save As)	Figure 10. Image acquired using a ScanCo Medical Xtreme CT scanner. High-res (TIF) version (Right-click and Save As)	Figure 11. Image acquired using a ScanCo Medical Xtreme CT scanner. High-res (TIF) version (Right-click and Save As)