Women Show Persistent Memory Impairment after Concussion

OAK BROOK, Ill. — Women may have a more difficult time than men in recovering from concussion, according to a new study published online in the journal Radiology.

Concussion, also known as mild traumatic brain injury (MTBI), is a common medical problem affecting cognitive function and quality of life in some individuals.

In most cases, patients who experience MTBI will recover fully, typically within three months. Ten to 15 percent of MTBI patients will continue to experience persistent disabling problems beyond three months, which can include post-traumatic headache, sleep disturbance, loss of balance, memory and other cognitive impairments, fatigue, and mood or affective disorders.

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Chi-Jen Chen, M.D.

The lasting effects of concussion have received widespread attention in recent years and caused growing concern, particularly among amateur and professional athletes and sports organizations. Several reports have indicated that female athletes suffer concussions at a higher rate than male athletes playing similar sports.

"In clinical practice, more women than men seek medical attention due to persistent symptoms after MTBI at a ratio of almost 2:1," said the study's lead author, Chi-Jen Chen, M.D., from the Department of Diagnostic Radiology and Brain and Consciousness Research Center at Taipei Medical University Shuang-Ho Hospital and superintendent at Chia-Yi Hospital in Taiwan. "We started to wonder whether there might be differences in MTBI outcomes between men and women."

Dr. Chen and colleagues set out to objectively evaluate gender differences in MTBI by using functional magnetic resonance imaging (fMRI) to analyze brain activation patterns during working memory tasks.

"Difficulty with working memory is a commonly reported impairment after MTBI," Dr. Chen said. "Since working memory is important for a wide variety of cognitive skills, compromised working memory could have significant effects on everyday life."

The researchers studied 30 patients with MTBI and 30 control patients. Both groups contained an equal number of men and women. Patients underwent an fMRI exam within one month after injury and a follow-up fMRI exam at six weeks after first scan. All participants underwent neuropsychological tests, including digit span and continuous performance test (CPT). Digit span is a short-term memory test measuring how many numbers a participant can remember in sequence. CPT measures a person's sustained and selective attention and impulsivity.

Initial fMRI results of the MTBI patients showed increased activation in working memory brain circuits in the men and decreased activation in the women, compared to the controls. At follow-up, men with MTBI returned to a normal activation pattern similar to the controls, whereas the women showed persistent hypoactivation, suggesting ongoing working memory problems.

Neuropsychological results showed that among the women, the total digit span score was lower in the MTBI group, compared to the control group.

"These findings provide evidence that female gender may be a risk factor for working memory impairment after MTBI," Dr. Chen said. "If so, more aggressive management should be initiated once MTBI is diagnosed in female patients."

Because fMRI has the potential to detect working memory impairment, predict outcome and monitor treatment effect, incorporation of fMRI into treatment protocol for MTBI may be advisable in the future, according to Dr. Chen. However, he cautions that further study needs to be done to validate these preliminary findings.