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RSNA Press Release

At A Glance:
  • Patients who had screening mammograms more often—less than 1.5 years between exams—had a significantly lower rate of cancer that had spread to the lymph nodes.
  • The study included 332 women with breast cancer identified by screening mammography between 2007 and 2010.
  • In 2009, the USPSTF recommended biennial screening for women between the ages of 50 and 74.

Mammography Screening Intervals May Affect Breast Cancer Prognosis

Released: December 4, 2013

Media Contacts: RSNA Newsroom 1-312-949-3233
Before 11/30/13 or after 12/5/13: RSNA Media Relations: 1-630-590-7762

Linda Brooks
1-630-590-7738
lbrooks@rsna.org
Maureen Morley
1-630-590-7754
mmorley@rsna.org

CHICAGO – In a study of screening mammography-detected breast cancers, patients who had more frequent screening mammography had a significantly lower rate of lymph node positivity—or cancer cells in the lymph nodes—as compared to women who went longer intervals between screening mammography exams. Results of the study were presented today at the annual meeting of the Radiological Society of North America (RSNA).

In its earliest stages, breast cancer is confined to the breast and can be treated by surgically removing the cancer cells. As the disease progresses, breast cancer cells may spread to the lymph nodes and then to other areas of the body.

"On its pathway to other places in the body, the first place breast cancer typically drains into before metastasizing is the lymph nodes," said Lilian Wang, M.D., assistant professor of radiology at Northwestern University/Feinberg School of Medicine in Chicago, Ill. "When breast cancer has spread into the lymph nodes, the patient is often treated both locally and systemically, with either hormone therapy, chemotherapy, trastuzumab or some combination of these therapies."

Historically, healthcare organizations, such as RSNA and the American Cancer Society (ACS), have recommended annual screening with mammography for women beginning at age 40. However, in 2009, the United States Preventive Services Task Force (USPSTF) announced a controversial new recommendation for biennial screening for women between the ages of 50 and 74.

"Our study looks at what would happen if the revised guidelines issued by USPSTF were followed by women," Dr. Wang said.

The retrospective study, conducted at Northwestern Memorial Hospital, included 332 women with breast cancer identified by screening mammography between 2007 and 2010. The women were divided into one of three groups, based on the length of time between their screening mammography exams: less than 1.5 years, 1.5 to three years and more than three years. There were 207, 73 and 52 patients in each category, respectively.

Controlling for age, breast density, high-risk status and a family history of breast cancer, the researchers determined that women in the less than 1.5-year interval group had the lowest lymph node positivity rate at 8.7 percent. The rate of lymph node involvement was significantly higher in the 1.5- to three-year and over three-year interval groups at 20.5 percent and 15.4 percent, respectively.

"Our study shows that screening mammography performed at an interval of less than 1.5 years reduces the rate of lymph node positivity, thereby improving patient prognosis," Dr. Wang said. "We should be following the guidelines of the American Cancer Society and other organizations, recommending that women undergo annual screening mammography beginning at age 40."

Co-authors are Ellen B. Mendelson, M.D., Paula M. Grabler, M.D., Riti Mahadevia, B.A., and Laura Billadello, M.D.

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Note: Copies of other RSNA 2013 news releases and electronic images will be available online at RSNA.org/press13 beginning Monday, Dec. 2.

RSNA is an association of more than 53,000 radiologists, radiation oncologists, medical physicists and related scientists, promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

Editor's note: The data in these releases may differ from those in the published abstract and those actually presented at the meeting, as researchers continue to update their data right up until the meeting. To ensure you are using the most up-to-date information, please call the RSNA Newsroom at 1-312-949-3233.

For patient-friendly information on mammography, visit RadiologyInfo.org.

Abstract:

Press conference video

Video clips (.mp4 format)

Video
Video 1. Radiologic technologist preparing patient for and performing mammogram.
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Video 2. Radiologist reviewing images.
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Video 3. Radiologist reviewing images.

Images (.JPG format)

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Figure 1. Patient 1: Bilateral MLO views from screening mammography in a 53 year old woman.

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Figure 2. Spot magnification view demonstrates an irregular spiculated mass with associated calcifications in the upper outer left breast. Ultrasound biopsy revealed invasive ductal carcinoma and DCIS.

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Figure 3. Patient 2: Screening mammogram in a 63 year old woman demonstrated calcifications in the upper outer left breast. Bilateral CC views shown here.

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Figure 4. Bilateral MLO views.

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Figure 5. Spot magnification view demonstrates suspicious linear branching calcifications. Stereotactic biopsy revealed DCIS.

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Figure 6. Patient 3: Screening mammogram in a 61 year old woman demonstrates architectural distortion in the upper outer left breast.

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Figure 7. Bilateral MLO views. Ultrasound biopsy demonstrated invasive mammary carcinoma and DCIS.

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RSNA 2013 Newsroom